Effects of Different Short-Term UV-B Radiation Intensities on Metabolic Characteristics of Porphyra haitanensis

The effects of ultraviolet (UV) radiation, particularly UV-B on algae, have become an important issue as human-caused depletion of the protecting ozone layer has been reported. In this study, the effects of different short-term UV-B radiation on the growth, physiology, and metabolism of Porphyra haitanensis were examined. The growth of P. haitanensis decreased, and the bleaching phenomenon occurred in the thalli. The contents of total amino acids, soluble sugar, total protein, and mycosporine-like amino acids (MAAs) increased under different UV-B radiation intensities. The metabolic profiles of P. haitanensis differed between the control and UV-B radiation-treated groups. Most of the differential metabolites in P. haitanensis were significantly upregulated under UV-B exposure. Short-term enhanced UV-B irradiation significantly affected amino acid metabolism, carbohydrate metabolism, glutathione metabolism, and phenylpropane biosynthesis. The contents of phenylalanine, tyrosine, threonine, and serine were increased, suggesting that amino acid metabolism can promote the synthesis of UV-absorbing substances (such as phenols and MAAs) by providing precursor substances. The contents of sucrose, D-glucose-6-phosphate, and beta-D-fructose-6-phosphate were increased, suggesting that carbohydrate metabolism contributes to maintain energy supply for metabolic activity in response to UV-B exposure. Meanwhile, dehydroascorbic acid (DHA) was also significantly upregulated, denoting effective activation of the antioxidant system. To some extent, these results provide metabolic insights into the adaptive response mechanism of P. haitanensis to short-term enhanced UV-B radiation.     

Cubic B-splines method for Hall and ion slip impacts on unsteady MHD rotating flow past a vertical moving porous plate

The heat and mass transfer of unsteady magnetohydrodynamic (MHD) flow of Newtonian fluid with Hall current and ion-slip currents due to vast possible engineering applications is very important in areas like power generators, MHD accelerators, refrigeration coils, electric transformers, and heating elements. A quality-based research on Hall and ion-slip consequences on the rotating unsteady MHD flow past an infinite perpendicular moving absorbent plate have not been performed. Therefore, the Hall and ion-slip consequences on rotating unsteady MHD flow past an infinite perpendicular moving absorbent plate have not been performed. The similarity transformations are engaged to transfer the governing partial differential equations within favor of the scheme of nonlinear ordinary differential equations and elucidated numerically making use of cubic B-splines collocation mechanism. The influences of felicitous parameters on basic equations are remarked on through graphical profiles. Even though the computational estimations of frictional forces, Nusselt number, and Sherwood number for various parameters are distributed in tabular format and exchanged of views comparatively.     

Design and fabrication of lutetium aluminum silicate glass and nanostructured glass for radiation detection

Flexible scintillating fiber plays an important role in X-ray radiation monitoring and high-resolution medical imaging, while construction of scintillating fiber derived from the commercial material system meet with limited success. Here, we report the design and successful fabrication of the Ce-activated lutetium aluminum silicate glass, nanostructured glass, and fiber, and explore their scintillating properties. The scintillating glass with optimized composition and optical properties is determined. The crystallization behavior of lutetium aluminum silicate glass is studied and the nanostructured glass embedded with orthorhombic Lu₂Si₂O₇ phase is successfully constructed for the first time. Importantly, the crystalline layer thickness of the nanostructured glass can be finely tuned and ~172.89% enhancement in the scintillating performance can be achieved. Furthermore, the fiber with large sized core is fabricated and its radiation response properties are tested. The results show that it exhibits high sensitivity and its scintillating emission is lineally dependent on the X-ray power, indicating the potential application for radiation detection.     

Ablative Radiotherapy Reprograms the Tumor Microenvironment of a Pancreatic Tumor in Favoring the Immune Checkpoint Blockade Therapy

The low overall survival rate of patients with pancreatic cancer has driven research to seek a new therapeutic protocol. Radiotherapy (RT) is frequently an option in the neoadjuvant or palliative settings for pancreatic cancer treatment. This study explored the effect of RT protocols on the tumor microenvironment (TME) and their consequent impact on anti-programmed cell death ligand-1 (PD-L1) therapy. Using a murine orthotopic pancreatic tumor model, UN-KC-6141, RT-disturbed TME was examined by immunohistochemical staining. The results showed that ablative RT is more effective than fractionated RT at recruiting T cells. On the other hand, fractionated RT induces more myeloid-derived suppressor cell infiltration than ablative RT. The RT-disturbed TME presents a higher perfusion rate per vessel. The increase in vessel perfusion is associated with a higher amount of anti-PD-L1 antibody being delivered to the tumor. Animal survival is increased by anti-PD-L1 therapy after ablative RT, with 67% of treated animals surviving more than 30 days after tumor inoculation compared to a median survival time of 16.5 days for the control group. Splenocytes isolated from surviving animals were specifically cytotoxic for UN-KC-6141 cells. We conclude that the ablative RT-induced TME is more suited than conventional RT-induced TME to combination therapy with immune checkpoint blockade.     

Radiation and slip effects on MHD Maxwell nanofluid flow over an inclined surface with chemical reaction

The numerical solutions of the upper-convected Maxwell (UCM) nanofluid flow under the magnetic field effects over an inclined stretching sheet has been worked out. This model has the tendency to elaborate on the characteristics of “relaxation time” for the fluid flow. Special consideration has been given to the impact of nonlinear velocity slip, thermal radiation and heat generation. To study the heat transfer, the modified Fourier and Fick's laws are incorporated in the modeling process. The mass transfer phenomenon is investigated under the effects of chemical reaction, Brownian motion and thermophoresis. With the aid of the similarity transformations, the governing equations in the ordinary differential form are determined and then solved through the MATLAB's package “bvp4c” numerically. This study also brings into the spotlight such crucial physical parameters, which are inevitable for describing the flow and heat transfer behavior. This has been done through graphs and tables with as much precision and exactitude as is possible. The ascending values of the magnetic parameter, the Maxwell parameter and the angle of the inclined stretching sheet cause decay in the dimensionless velocity while an assisting behavior of the thermal and concentration buoyancy parameters is noticed.     

An automated treatment planning strategy for highly noncoplanar radiotherapy arc trajectories

Radiation therapy is a technology-driven cancer treatment modality that has experienced significant advances over the last decades, due to multidisciplinary contributions that include engineering and computing. Recent technological developments allow the use of noncoplanar volumetric modulated arc therapy (VMAT), one of the most recent photon treatment techniques, in clinical practice. In this work, an automated noncoplanar arc trajectory optimization framework designed in two modular phases is presented. First, a noncoplanar beam angle optimization algorithm is used to obtain a set of noncoplanar irradiation directions. Then, anchored in these directions, an optimization strategy is proposed to compute an optimal arc trajectory. The computational experiments considered a pool of twelve difficult head-and-neck tumor cases. It was possible to observe that, for some of these cases, the optimized noncoplanar arc trajectories led to significant treatment planning quality improvements, when compared with coplanar VMAT treatment plans. Although these experiments were done in a research environment treatment planning software (matRad), the conclusions can be of interest for a clinical setting: automated procedures can simplify the current treatment workflow, produce high-quality treatment plans, making better use of human resources and allowing for unbiased comparisons between different treatment techniques.     

Effect of nonlinear thermal radiation on 3D magneto slip flow of Eyring-Powell nanofluid flow over a slendering sheet with binary chemical reaction and Arrhenius activation energy

An analysis is performed to study the combined effects of nonlinear thermal radiation, Arrhenius activation energy, chemical reaction and heat generation/absorption on the steady three-dimensional magnetohydrodynamic flow of Eyring-Powell nanofluid flow over a slendering stretchable sheet with velocity, thermal and solutal slips. The prevailing partial differential equations are transmuted into coupled non-linear ordinary differential equations via with the suitable similarity transformations. The resultant non-linear coupled differential equations are solved numerically by using the R-K 4^th order method along with shooting scheme. The results are calculated to measure the influence of sundry parameters on velocity, temperature, concentration, shear stress, temperature gradient and concentration gradient are presented graphically and in tabular form. It is noticed that the temperature is more impactable for higher values of radiative heat transport. The local Sherwood number decays exponentially for all the values of the chemical reaction parameter. We compared the present results for the limiting cases with previously published results, which has shown reliability and efficiency.     

两种3D打印用雾化Ti-6Al-4V粉末的对比研究

本研究分别利用水冷铜坩埚真空感应熔炼气雾化(VIGA-CC)和等离子旋转电极(PREP)两种技术制备出球形Ti-6Al-4V合金粉末,作者利用SEM、同步辐射CT扫描-三维重建和氩气含量测试等分析手段对不同粒径的Ti-6Al-4V合金粉末的孔洞缺陷和氩气含量、硬度值进行了表征。实验结果表明, VIGA-CC粉末粒度分布宽,细粉收得率较多,粉末粒度分布在40~180 μm之间, PREP粉末的粒度分布较窄,主要集中在110~180 μm之间；金属粉末内部的孔隙率、气体含量和孔尺寸随着粉末粒度的增大而增大,且同一粒径范围内VIGA-CC粉末的气孔概率多于PREP粉末；随着粉末粒径减小,粉末截面组织逐渐细化,其硬度值逐渐升高,整体上VIGA-CC粉末硬度值高于PREP粉末。     

Multi-field coupling thermo-acoustic radiation using free-standing nano-thin films in a static magnetic field

Abstract

Thermo-acoustic radiation from nano-thin film has been widely reported these years. In this paper, a static magnetic field is introduced to enhance the acoustic power in the multi-field thermo-acoustic generation. The coupled thermo-acoustic system in a static magnetic field shares the same acoustical unit with very few additional components. In the presence of a static magnetic field, thin-film vibration is excited instead of being still in the classical thermo-acoustic system. Not surprisingly, a steady magnetic field has very little impact on the thermo-acoustic generation system when a constant amplitude sinusoidal current is introduced. The oscillation perpendicular to the nano-thin film is driven by the electromagnetic force. The system response of thermo-acoustics and magneto-acoustics can be generally matched when suitable parameters are introduced. The acoustical pressure output can be significantly improved in the presence of a static magnetic field although more electrical input power should be provided in the multi-field thermo-acoustic system. Evidently, the coupled multi-field acoustical system is able to handle more electrical power input and the power input can be more easily dissipated relatively. The results show that the acoustic response of this new multi-filed coupled system can be significantly improved as compared to the classical system without magnetic effects.